BREX system ofEscherichia colidistinguishes self from non-self by methylation of a specific DNA site
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بررسی جامعه شناسی منطق بر اساس کتاب "weaving self-evidence a sociology of logic" by "claude rosental"
این رساله از چهار فصل تشکیل شده است.نویسنده کتاب در فصل اول در تلاش است تا به جهان دور از دسترس منطق دانان دسترسی پیدا کند در این راستا در ابتدا به سابقه و پیشینه جامعه شناسی ریاضیات و منطق می پردازد. او رویکرد های جامعه شناختی و تجربی به منطق را مورد مداقه قرار می دهد و از این میان شیوه روش قوم شناختی رابر می گزیند. رزنتال اعتقاد دارد نگاه صلب و تغییر ناپذیر به منطق ناصواب است. منطق همانند هر ...
15 صفحه اولSelf-methylation of BspRI DNA-methyltransferase.
The DNA (cytosine-5)-methyltransferase (m5C-MTase) M.BspRI is able to accept the methyl group from the methyl donor S-adenosyl-L-methionine (AdoMet) in the absence of DNA. Transfer of the methyl group to the enzyme is a slow reaction relative to DNA methylation. Self-methylation is dependent on the native conformation of the enzyme and is inhibited by S-adenosyl-L-homocysteine, DNA and sulfhydr...
متن کاملA population-epigenetic model to infer site-specific methylation rates from double-stranded DNA methylation patterns.
Cytosine methylation is an epigenetic mechanism in eukaryotes that is often associated with stable transcriptional silencing, such as in X-chromosome inactivation and genomic imprinting. Aberrant methylation patterns occur in several inherited human diseases and in many cancers. To understand how methylated and unmethylated states of cytosine residues are transmitted during DNA replication, we ...
متن کاملOptogenetic regulation of site-specific subtelomeric DNA-methylation
Telomere length homeostasis, critical for chromosomal integrity and genome stability, is controlled by intricate molecular regulatory machinery that includes epigenetic modifications. Here, we examine site-specific and spatiotemporal alteration of the subtelomeric methylation of CpG islands using optogenetic tools to understand the epigenetic regulatory mechanisms of telomere length maintenance...
متن کاملSite-specific detection of DNA methylation utilizing mCpG-SEER.
Currently there are no direct methods for the sequence-specific detection of DNA-methylation at CpG dinucleotides, which provide a possible diagnostic marker for cancer. Toward this goal, we present a methodology termed mCpG-SEquence Enabled Reassembly (mCpG-SEER) of proteins utilizing a split green fluorescent protein (GFP) tethered to specific DNA recognition elements. Our system, mCpG-SEER, ...
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ژورنال
عنوان ژورنال: Nucleic Acids Research
سال: 2018
ISSN: 0305-1048,1362-4962
DOI: 10.1093/nar/gky1125